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Gall‐bladder perforation after long‐term dapsone therapy
Author(s) -
CHOY A. M.,
LANG C. C.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00254.x
Subject(s) - medicine , dapsone , laparotomy , vomiting , perforation , surgery , abdominal pain , cholecystectomy , dermatology , materials science , punching , metallurgy
. A 65‐year‐old man on maintenance dapsone therapy for dermatitis herpetiformis for 30 years was admitted to hospital with acute abdominal pain and vomiting. Investigations revealed a Heinz body haemolytic anaemia. Worsening symptoms prompted an emergency laparotomy that revealed a perforated gall bladder with pigmented biliary calculi. In previous reviews of the haematological abnormalities associated with dapsone therapy, life‐threatening cholecystitis has not been described.