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Kidney function and cardiovascular risk factors in non‐insulin‐dependent diabetics (NIDDM) with microalbuminuria
Author(s) -
SCHMITZ A.,
CHRISTENSEN T.,
MØLLER A.,
MOGENSEN C. E.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00244.x
Subject(s) - microalbuminuria , medicine , renal function , albuminuria , diabetes mellitus , endocrinology , insulin , risk factor
. Microalbuminuria in non‐insulin‐dependent diabetes (NIDDM) is a strong predictor of increased mortality. The major causes of death are cardiovascular, whereas end‐stage renal failure is of low frequency. To define kidney function and the presence of some assumed cardiovascular risk factors, we compared a group of 19 microalbuminuric NIDDM patients (M), of mean age (±SD) 65 ± 4 years, and known duration of diabetes 8 ± 7 years, with 19 randomly selected matched normoalbuminuric patients (N). Seven macroalbuminuric patients (P) were also studied. Glomerular filtration rate (GFR) did not differ between N and M, whereas kidney volume was increased in M (260.3 ± 54.1 ml 1.73 m −2 ) compared to N (220.4 ± 44.8 ml 1.73 m −2 ; P =0.018). The frequency of cardiac disease increased with increasing albuminuria. Glycaemic control did not differ between the groups, but fasting plasma C‐peptide levels increased from 2.8 ± 1.1 μg l −1 in N, to 3.7 ± 1.7 μg l −1 in M ( P =0.08), and to 4.2 ± 1.9 μg l −1 ( P= 0.03) in P. The lipoprotein profile showed no significant differences, although the LDL cholesterol /HDL cholesterol (LDL‐C/HDL‐C) ratio tended to rise. A significant correlation was found between C‐peptide and LDL‐C/HDL‐C ( r =0.5; P < 10 −3 ). In conclusion, GFR was not increased, and did not differ between N and M, whereas kidney volume was enhanced in M. Several assumed cardiovascular risk factors showed values of M intermediate between those of N and P.