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Pituitary‐thyroid axis, prolactin and growth hormone in patients with acute stroke
Author(s) -
OLSSON T.,
ASPLUND K.,
HÄGG E.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00233.x
Subject(s) - prolactin , medicine , hormone , thyrotropin releasing hormone , endocrinology , growth hormone , hypothalamic–pituitary–thyroid axis , thyroid , stroke (engine) , thyroid stimulating hormone , thyroid hormones , mechanical engineering , engineering
. The pituitary‐thyroid axis, serum prolactin and growth hormone levels were studied in 29 patients within 9 d of onset of acute ischaemic stroke. When compared to a control group of 80‐year‐old volunteers ( n =33), stroke patients were found to have elevated free thyroxine indices ( P =0.008), after adjustment for age and sex. Seventeen (81%) of the stroke patients showed a paradoxical rise in growth hormone in response to thyrotropin releasing hormone (TRH). In a multiple regression model, disorientation was associated with a low thyrotropin response to TRH ( P =0.02 and P =0.04; 20 and 60 min after TRH, respectively). Disorientation was also positively correlated with the prolactin response to TRH ( P =0.045 after 60 min). Growth hormone levels were predicted by extensive motor impairment ( P =0.02). In conclusion, changes in pituitary and thyroid hormones were commonly observed after stroke and were closely associated with cognitive and/or motor impairment.