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Comparison of the side‐effects of pindolol and atenolol in the treatment of hypertension
Author(s) -
ABRAHAMSEN A. M.,
DIGRANES Ø.,
GISHOLT K.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00221.x
Subject(s) - pindolol , atenolol , medicine , bradycardia , anesthesia , beta blocker , side effect (computer science) , diltiazem , essential hypertension , beta (programming language) , heart rate , propranolol , blood pressure , calcium , heart failure , computer science , programming language
. A double‐blind multicentre study of 349 hypertensive patients was performed to compare the side‐effects of the two beta‐blockers atenolol (selective beta 1 ‐blocker) and pindolol (beta 1 ‐ and beta 2 ‐blocker with Intrinsic sympathomimetic activity (ISA)) in equipotential doses (100 mg atenolol vs. 15 mg pindolol). Male and female patients aged 20‐65 years with essential hypertension WHO stages I and II were included. Patients were examined 1 and 6 months after the start of treatment, and side‐effects were recorded. The antihypertensive effect was similar for the two drugs. After 1 month there was significantly less bradycardia ( P < 0.01), cold hands and feet ( P < 0.05) and tiredness ( P < 0.02) in the pindolol group, and less sleep disturbance ( P < 0.02) in the atenolol group. After 6 months there was no significant difference in sleep disturbance, but the differences in the other side‐effects remained significant.