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Measurement of leukotriene B4 in arterial blood of asthmatic patients during wheezing attacks
Author(s) -
SHINDO K.,
MATSUMOTO Y.,
HIRAI Y.,
SUMITOMO M.,
AMANO T.,
MIYAKAWA K.,
MATSUMURA M.,
MIZUNO T.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00200.x
Subject(s) - medicine , asthma , cardiology , anesthesia
Abstract. To investigate whether leukotriene B4 is present in the arterial blood of asthmatic patients during wheezing attacks. 20 ml of arterial blood was drawn from the inguinal artery of five patients. Leukotriene B4 was detected in all five individuals, and its identity was confirmed by a combination of high pressure liquid chromatography and radioimmunoassay techniques. The concentration of leukotriene B4 was 48.34 ± 16.27 pg ml −1 (mean value ± SE). However, in five control subjects the leukotriene B4 concentration was found to be 9.43 ± 5.44 pg ml −1 . Thus there was a significant difference between the two groups (P < 0.05). These results suggest that leukotriene B4 may be important in elucidation of the pathogenesis of bronchial asthma.