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Azathioprine and allopurinol: a potentially dangerous combination
Author(s) -
RAMAN G. VENKAT,
SHARMAN V. L.,
LEE H. A.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00195.x
Subject(s) - allopurinol , medicine , azathioprine , discontinuation , complication , combination therapy , surgery , disease
. We report the association of leucopenia and anaemia in five patients given a combination of azathioprine and allopurinol. Three subjects were renal transplant recipients with mild to moderate impairment of graft function. The complication appeared between 4 and 6 weeks following initiation of the combination therapy. Discontinuation of one of the two drugs resulted in full recovery within 4–8 weeks.