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Pre‐ and postoperative evaluation of renal function with five different tests in patients with primary hyperparathyroidism
Author(s) -
KRISTOFFERSSON A.,
BACKMAN C.,
GRANQVIST K.,
JÄRHULT J.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00166.x
Subject(s) - medicine , renal function , urology , creatinine , hypercalcaemia , hyperparathyroidism , parathyroidectomy , endocrinology , parathyroid hormone , calcium
. Renal function was investigated immediately before and 1 year following parathyroidectomy in 19 patients with moderate hypercalcaemia. On both occasions, all patients underwent five different tests of glomerular and tubular function: plasma creatinine, creatinine clearance, 51 Cr‐EDTA‐clearance, β 2 ‐microglobulin excretion and the desmopressin test. Glomerular filtration rate, as assessed by plasma creatinine and clearance of both creatinine and 51 Cr‐EDTA, was normal in most patients, and was little affected by restoration of normocalcaemia. Renal concentrating capacity, as determined by the desmopressin test, was abnormally low in 14 of 19 patients, but increased significantly after surgery. It is concluded that serious renal damage is seldom encountered in present‐day HPT patients, but that a treatable decrease in renal concentrating capacity often exists.