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Lipid peroxides, glutathione peroxidase, high density lipoprotein subfractions and apolipoproteins in young adults
Author(s) -
LUOMA P. V.,
STENGÅRD J.,
KORPELA H.,
RAUTIO A.,
SOTANIEMI E. A.,
SUVANTO E.,
MARNIEMI J.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00161.x
Subject(s) - apolipoprotein b , lipid peroxide , cholesterol , medicine , endocrinology , glutathione peroxidase , lipoprotein , high density lipoprotein , peroxide , peroxidase , biochemistry , enzyme , lipid peroxidation , chemistry , oxidative stress , superoxide dismutase , organic chemistry
. Lipid peroxides have been implicated in the initiation of atherogenesis. In this study of 23 young healthy subjects, high levels of serum lipid peroxides were associated with low serum HDL 2 cholesterol concentrations and low HDL 2 /HDL 3 cholesterol and apolipo‐protein A‐I/A‐II ratios. Low levels of LDL cholesterol and apolipoprotein B, and low apolipoprotein B/A‐I ratios were typical of subjects with high serum glutathione peroxidase activities. Serum lipid peroxide levels varied widely in subjects without abnormal cholesterol, HDL cholesterol or LDL cholesterol concentrations. This variation may play a role in the frequent occurrence of coronary artery disease in normolipidaemic individuals.