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Increased turnover of very low density lipoprotein triglyceride during treatment with cholestyramine in familial hypercholesterolaemia
Author(s) -
ANGELIN B.,
LEIJD B.,
HULTCRANTZ R.,
EINARSSON K.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00143.x
Subject(s) - very low density lipoprotein , medicine , cholestyramine , triglyceride , endocrinology , lipoprotein , catabolism , cholesterol , bile acid , intermediate density lipoprotein , metabolism
. Kinetics of very low density lipoprotein (VLDL) triglyceride were determined in seven patients with heterozygous familial hypercholesterolaemia, using a 3 H‐glycerol technique. The study was repeated after 5–7 weeks of therapy with the bile acid‐binding resin, cholestyramine. The rate of synthesis of VLDL triglyceride was increased by 85% ( P < 0.05) during resin therapy. Simultaneously, the fractional catabolic rate of VLDL was increased by 40% ( P < 0.02), so that only a moderate increase in plasma concentration was observed. Repeated measurements of VLDL size by electron microscopy (before, 1 week, and 5–7 weeks after initiation of therapy) indicated that a transient increase in VLDL size occurred in response to cholestyramine. The results are consistent with a stimulatory effect of bile acid sequestrants on VLDL triglyceride production and indicate that, in most subjects, a compensatory increase in VLDL triglyceride removal occurs.