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Dietary marine lipids suppress murine autoimmune disease
Author(s) -
ROBINSON D. R.,
TATENO S.,
KNOELL C.,
OLESIAK W.,
XU L.,
HIRAI A.,
GUO M.,
COLVIN R. B.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb01459.x
Subject(s) - phosphatidylethanolamine , autoimmune disease , medicine , disease , spleen , immunology , fish oil , biochemistry , biology , phospholipid , fish <actinopterygii> , phosphatidylcholine , membrane , fishery
. Dietary marine lipids reduce both mortality and the severity of glomerulonephritis in inbred murine strains which develop spontaneous autoimmune disease. The protective effects of marine lipids appear to be accounted for by the major n‐3 fatty acids in these preparations, 20:5 and 22:6. The n‐3 fatty acids in dietary fish oil are extensively incorporated into several lipid classes in the spleen of autoimmune mice, including phosphatidylinositol, phosphatidylethanolamine, plasmalogens and saturated ether‐linked phospholipids as well as diacylphosphoglycerides. The effects of dietary marine lipids on autoimmune disease in experimental models are highly specific. Careful controlled trials will be required to establish the role of dietary marine lipids in the therapy of human autoimmune disease.