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Effects of dietary supplementation with cod liver oil on monocyte thromboplastin synthesis, coagulation and fibrinolysis
Author(s) -
HANSEN J.B.,
OLSEN J. O.,
WILSGÅRD L.,
ØSTERUD B.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb01447.x
Subject(s) - fibrinolysis , medicine , endocrinology , thromboxane , thromboplastin , fibrinogen , arachidonic acid , plasminogen activator , eicosapentaenoic acid , partial thromboplastin time , thromboxane b2 , monocyte , fish oil , factor vii , cod liver oil , coagulation , fatty acid , platelet , polyunsaturated fatty acid , chemistry , biochemistry , biology , enzyme , fishery , fish <actinopterygii>
. In a controlled trial 40 healthy persons (20 men and 20 women) were tested before and after a daily supplement with 25 ml cod liver oil for 8 weeks. The diet increased the eicosapentaenoic acid (20:5 n‐3) content in serum and monocytes four‐to five‐fold whereas the arachidonic acid (20:4 n‐6) content decreased 10–20% in both serum and monocytes. Stimulation of blood with a low concentration of lipopolysaccharides (LPS) revealed a 40% suppression of LPS‐induced thromboplastin synthesis in the monocytes after 8 weeks of CLO intake. In the same LPS stimulation system, men were found to generate significantly more thromboxane B 2 than women (4.9 ng ml −1 versus 3.4 ng ml −1 ). After the CLO supplementation for 8 weeks the thromboxane B 2 was reduced by a mean of 70% in women and 60% in men. Factor VII and fibrinogen appeared to be unaltered by CLO intake. Determination of whole blood clot lysis time and tissue plasminogen activator (t‐PA) did not indicate any significant influence of n‐3 fatty acids on fibrinolysis.