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Monitoring kidney function in diabetic nephropathy
Author(s) -
GROTH S.,
PETERSEN C.,
DIRKSEN A.,
PARVING H.H.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb01406.x
Subject(s) - medicine , renal function , urology , diabetic nephropathy , nephropathy , diabetes mellitus , confidence interval , bolus (digestion) , venous blood , kidney disease , liter , endocrinology
Groth S, Petersen C, Dirksen A, Parving H.‐H (Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital and Rigshospitalet, Hvidøre Hospital, Copenhagen. Denmark). Monitoring kidney function in diabetic nephropathy. We investigated the validity of a one plasma sample method (I) compared with a multiple plasma sample method (II) for routine clinical determination of glomerular filtration rate (GFR) in 35 insulin‐dependent diabetic patients suffering from nephropathy. GFR was measured after an intravenous bolus injection of 100 μCi 51 Cr‐EDTA by determination of plasma radioactivity in venous blood samples taken from the other arm 180, 200, 220 and 240 min after the injection (II). The plasma radioactivity in the sample drawn 240 min after injection was used in method I. During the mean investigation period of 32 months (12–62 months) a total of 184 GFR determinations were performed. The average interval between the GFR measurements was 6 months (1–21 months). In 127/184 of the study intervals method I indicated a decrease in GFR. The corresponding figure for method II was almost identical, 130/184. The mean decline in GFR was 8.1 ± 7.2 and 7.8 ± 6.9 ml year −1 1.73 m −2 using methods I and II, respectively (NS). The methods essentially provided the same GFR values in absolute terms ( r = 0.98, P < 0.001). We conclude that the one plasma sample method can be used as a valid routine technique in non‐uraemic patients with nephropathy.