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The interaction between indomethacin and captopril or enalapril in healthy volunteers
Author(s) -
KOOPMANS P. P.,
VAN MEGEN T.,
THIEN T.,
GRIBNAU F. W. J.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb01370.x
Subject(s) - enalapril , captopril , medicine , pharmacology , angiotensin converting enzyme , blood pressure
Koopmans PP, van Megen T, Thien T. Gribnau FWJ (Department of Medicine, Division of General Internal Medicine, and Department of Pharmacology, Sint Radboud Hospital, University of Nijmegen, The Netherlands). The interaction between indomethacin and captopril or enalapril in healthy volunteers. In this study eight healthy volunteers were involved in a randomized, cross‐over trial in which they were treated with either 25 mg of captopril b.i.d. or 20 mg of enalapril o.i.d. alone or in combination with 50 mg of indomethacin b.i.d. in order to detect a difference between both converting enzyme inhibitors when interacting with indomethacin. Before and after each 4‐d treatment period, blood pressure (determined by random zero sphygmomanometer), body weight, plasma renin activity, angiotensin converting enzyme, plasma potassium, serum creatinine and the 24‐h urinary excretion of 6‐keto‐prostaglandin F 1 α were measured. Indomethacin attenuated the decrease of supine diastolic blood pressure during treatment with captopril, but not with enalapril. However, the initial decrease of blood pressure on captopril was greater than on enalapril. Both converting enzyme inhibitors had no effect on the urinary excretion of 6‐keto‐prostaglandin F 1 α, while indomethacin reduced it. The results suggest a difference between captopril and enalapril in interaction with indomethacin.