Premium
Plasma zinc concentrations during the first 2 years after diagnosis of insulin‐dependent diabetes mellitus: a prospective study
Author(s) -
MELCHIOR T.,
SIMONSEN K. WIESE,
JOHANNESSEN A. C.,
BINDER C.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb01353.x
Subject(s) - medicine , diabetes mellitus , zinc , endocrinology , insulin , albumin , materials science , metallurgy
Melchior T, Wiese Simonsen K, Johannessen AC, Binder C (Steno Memorial Hospital, Gentofte and Department of Chemistry AD, Royal Danish School of Pharmacy. Copenhagen. Denmark). Plasma zinc concentrations during the first 2 years after diagnosis of insulin‐dependent diabetes mellitus: a prospective study. Studies of zinc status in insulin‐dependent diabetes mellitus (IDDM) have shown contradictory results. Zinc is essential for many enzymes involved in the human metabolism and may play a role in the biosynthesis and storage of insulin in the B‐cell. We therefore prospectively followed 26 patients (14 males and 12 females) with newly diagnosed IDDM in order to determine the plasma zinc variation at the time of diagnosis and after 1, 3, 6, 12 and 24 months. Seventy‐two healthy persons (36 males and 36 females) served as controls. Only minor differences in plasma zinc were demonstrated during the first 2 years of IDDM. A sex difference was found in healthy controls but only after 24 months in the diabetics. Quantitative changes of the B‐cell function, development of insulin antibodies, age. body weight and serum albumin did not correlate with the course of plasma zinc.