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Cod liver oil does not reduce ventricular extrasystoles after myocardial infarction
Author(s) -
HARDARSON T.,
KRISTINSSON Å.,
SKÚLADÓTTIR G.,
ÁSVALDSDÓTTIR H.,
SNORRASON S. P.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb01350.x
Subject(s) - medicine , eicosapentaenoic acid , fish oil , cod liver oil , myocardial infarction , ingestion , incidence (geometry) , cardiology , polyunsaturated fatty acid , fatty acid , fish <actinopterygii> , fishery , biochemistry , chemistry , physics , optics , biology
Hardarson T. Kristinsson Å, Skúladóttir G. Åsvaldsdóttir H. Snorrason SP (Department of Medicine, National University Hospital, Landspitalinn. and the Science Institute of University of Iceland. Reykjavik, Iceland). Cod liver oil does not reduce ventricular extrasystoles after myocardial infarction. Previous work has shown that in experimental animal models a lower incidence of arrhythmias and sudden death was observed if the animals were fed cod liver oil or fish oil. After a 48‐h control period starting, on average, 8 days after the onset of symptoms, 18 men who were recovering from acute myocardial infarction were given 20 ml d −1 cod liver oil for 6 weeks, either immediately after the control period, weeks 0–6 ( n = 10). or during weeks 6–12 ( n = 8). Forty‐eight‐hour Holter monitoring was carried out before cod liver oil administration and at the end of weeks 6 and 12. The eicosapentaenoic acid content of plasma phospholipids was increased by 230% during cod liver oil administration. However, no signficant change was observed in the 24‐h prevalence of ventricular extrasystoles or other arrhythmias during the study period. The mean In number of ventricular extrasystoles was 2.95 ± 0.51 (± SEM) during cod liver oil ingestion and 2.63 ± 0.30 when not taking cod liver oil.