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Fatty acid composition of serum lipids in patients with a coronary bypass operation
Author(s) -
MARNIEMI J.,
LEHTONEN A.,
INBERG M.,
NIITTYMÄKI K.,
MAATELA J.,
ALANEN E.,
SEPPÄNEN A.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb00092.x
Subject(s) - polyunsaturated fatty acid , medicine , linoleic acid , coronary artery disease , arachidonic acid , endocrinology , apolipoprotein b , cholesterol , lipoprotein , fatty acid , biochemistry , chemistry , enzyme
. The fatty acid composition of serum phospholipids and cholesteryl esters was analysed in 71 male patients with angiographically defined three‐vessel coronary artery disease (CAD) selected for a coronary bypass operation. Their 71 control subjects were matched according to age, sex, smoking, relative weight, and absence of CAD. The concentrations of fatty acids, 14:0, 16:0 and 16:1 of the serum phospholipids, were significantly ( P < 0.01, P < 0.05 and P < 0.01, respectively) higher in CAD patients than in the controls. On the other hand, linoleic (18:2Ω6), linolenic (18:3Ω3) and arachidonic (20:4Ω6) acids were at a significantly lower level in the patients when compared to the controls. The polyunsaturated/saturated fatty acids (P/S) ratio in serum phospholipids was significantly ( P < 0.01) lower in the patients than in the controls. In the cholesteryl ester fraction the results paralleled those of the phospholipids. Significant correlations were obtained between the polyunsaturated fatty acids and the high density lipoprotein cholesterol or apolipoprotein A‐I in the control subjects but most of these correlations were absent in the patients. Our present results further support the importance of linoleic acid in the protection against atherosclerosis. However, no unequivocal evidence on the possible beneficial effect of long‐chain Ω3‐fatty acids in comparison with Ω6‐acids was obtained.