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Vitamin D, parathyroid hormone, and bone mineral content of lumbar spine and femur in primary biliary cirrhosis
Author(s) -
ALMDAL T.,
SCHAADT O.,
JØRGENSEN J. VESTERDAL,
LINDGREEN P.,
RANEK L.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb00065.x
Subject(s) - medicine , primary biliary cirrhosis , femoral neck , parathyroid hormone , endocrinology , vitamin d and neurology , calcium metabolism , osteomalacia , bone mineral , osteoporosis , bone disease , calcium , gastroenterology
. In order to elucidate the pathogenesis and degree of osteopoenia in primary biliary cirrhosis (PBC) we conducted a cross‐sectional study of 47 non‐selected female patients with biopsy‐proven PBC. Bone mineral content (BMC) of the lumbar spine, femoral neck and femoral shaft was determined using dual photon absorptiometry. Compared to healthy females of corresponding decades the PBC patients exhibited significantly decreased mean BMC‐values in lumbar spine (88%, P < 0.05) and femoral neck (92%, P < 0.05) but not in femoral shaft (96%, NS). Bone mineral content was not significantly associated with duration of liver disease, impairment of liver function (serum concentrations of albumin, clotting factors II + VII + X, bilirubin, alkaline phosphatase galactose elimination capacity or histology), variables reflecting calcium homeostasis (serum concentrations of ionized calcium, parathyroid hormone, vitamin D binding protein, 25‐hydroxy vitamin D 3 and 1,25‐dihydroxy vitamin D 3 ) or previous treatment with glucocorticosteroids. In view of our negative findings we suggest that future studies in this field should focus on physical activity and female sex hormones as determinants for the prevention of osteopoenia in females with primary biliary cirrhosis.