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Platelet sodium and potassium ATP activity and noradrenaline efflux rate in relation to autonomic and peripheral nerve function in insulin‐dependent diabetic patients
Author(s) -
BERGSTRÖM B.,
MATTIASSO I.,
ROSÉN I.,
LILJA B.,
SUNDKVIST G.
Publication year - 1989
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1989.tb00061.x
Subject(s) - medicine , endocrinology , platelet , diabetes mellitus , insulin , atpase , autonomic nerve , peripheral neuropathy , chemistry , enzyme , biochemistry
Abstract. Low sodium and potassium adenosine triphosphatase (ATPase) activity has been proposed as a mechanism behind diabetic neuropathy. In this study the platelet ATPase activity and platelet noradrenaline efflux rate were determined in 47 insulin‐dependent diabetes mellitus (IDDM) patients and 20 controls. Ulnar motor conduction velocities, tested in a subgroup, were lower in patients than in controls (52.7 ± 1.3 m s −1 vs . 61.3 ± 1.4 m s −1 ; P < 0.001). Platelet ATPase activity tended to be increased in the patients compared with the controls (29.9 ± 1.0 times 10 −3 min −1 vs . 26.9 ± 1.1 times 10 −3 min −1 ; NS). In ulnar nerve function tested subjects, ATPase activity was higher in patients than in controls (31.2 ± 1.7 times 10 −3 min −3 vs . 25.9 ± 1.3 times 10 −3 min −1 ; P < 0.01). The platelet noradrenaline efflux rate tended to be higher in patients with lower brake indices, a sign of autonomic neuropathy, than in controls (29.0 ± 3.0 times 10 −3 min −1 vs . 21.2 ± 0.9 times 10 −3 min −1 ; P < 0.05). The platelet ATPase activity was not decreased in IDDM patients, however, a connection between diabetic autonomic neuropathy and platelet transmittor leakage was indicated.