Premium
TUBULAR REABSORPTION OF PHOSPHATE AND CALCIUM IN PRIMARY HYPERPARATHYROIDISM
Author(s) -
Andersen P.,
Mosekilde L.
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00100.x
Subject(s) - primary hyperparathyroidism , medicine , calcium , creatinine , hyperparathyroidism , reabsorption , endocrinology , renal function , phosphate , gastroenterology , urology , kidney , chemistry , biochemistry
Phosphate clearance (Cl ph ) and the renal tubular reabsorption of phosphate and calcium (TRP and TRCa) have been determined in 90 patients, 31 with primary hyperparathyroidism (PHP), 9 with non‐parathyroid hypercalcemia, 24 with nephrolithiasis and 26 with other diseases in order to determine the value of these parameters in diagnosing PHP. A high Cl ph (≥ 15 ml/min) was seen more commonly in patients with PHP than among patients in the other groups. Measurement of this parameter, however, was not found to be of any definite value in diagnosing PHP. Renal TRP < 80% was found in 35.5% of patients with PHP, in 33.3% of patients with non‐parathyroid hypercalcemia, in 0% of patients with nephrolithiasis and in 11.5% of patients with other diseases. The TRP, however, was found to vary with creatinine clearance (Cl er ) and thus the TRP could be used as a diagnostic parameter of PHP in patients with normal Cl er (≥ 70 ml/min). The renal TRCa was found to be of aid in diagnosing PHP in patients with greatly increased serum calcium values. Thus a complete differentiation was found between patients with PHP and patients with non‐parathyroid hypercalcemia when the TRCa was compared with the serum calcium concentration.