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MUSCLE AND LIVER SERUM ENZYME ACTIVITIES IN HEALTHY VOLUNTEERS GIVEN ALCOHOL ON A DIET POOR IN CARBOHYDRATES
Author(s) -
Hed Ragnar,
Nygren Arne,
Sundblad Lars
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00095.x
Subject(s) - ingestion , medicine , alcohol , carbohydrate , endocrinology , myopathy , enzyme , pathogenesis , physiology , biochemistry , biology
In order to elucidate the importance of a short‐age of carbohydrates in the food for the occurrence of alcoholic muscle disease, muscle and liver enzymes (LDH isoenzymes, GOT, GPT and CPK) have been assayed in the serum of six healthy volunteers after alcohol ingestion on a diet poor in carbohydrates (group I). Twelve healthy subjects fed the carbohydrate‐poor diet without alcohol addition (group II) and six other subjects given alcohol when on the average Swedish diet (group III) served as controls. In the group given alcohol in addition to the carbohydrate‐poor diet an increase of LDH‐1 and LDH‐2 was observed. No other noticeable enzyme increases were registered. It is concluded that a lack of carbohydrate may be a factor involved in the pathogenesis of alcoholic myopathy.