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VASCULAR RESISTANCE IN HYPOTHERMICALLY PERFUSED KIDNEYS FOLLOWING ONE HOUR OF WARM ISCHAEMIA
Author(s) -
Løkkegaard Hans,
Bilde Torben
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00079.x
Subject(s) - medicine , vascular resistance , papaverine , ischemia , perfusion , anesthesia , renal artery , kidney , cardiology , hemodynamics
The vascular resistance in hypothermically perfused rabbit kidneys following one hour of warm ischaemia has been investigated in 45 experiments. As perfusate medium was used 5% low molecular weight dextran in balanced salt solution (TIS‐U‐SOL) to which 5 mg% papaverine was added. One hour of warm ischaemia following death (cardiac arrest) either by suffocation or bleeding, and with an agonal phase from 3 to 15 min, increased the vascular resistance about three times compared to a group with only a short period of warm ischaemia. Clamping of the renal artery for one hour revealed a similar increase in the vascular resistance, while simultaneous clamping of the renal artery and vein only increased the vascular resistance by about one‐third compared to the group with a short period of warm ischaemia. Heparinization of the animals before a one‐hour ischaemic period prevented a pronounced increase in the vascular resistance during the first 10 to 20 min of perfusion.