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TRANSFERRIN EXCRETION IN PATIENTS WITH PROTEINURIA
Author(s) -
Kistner Sten,
Norberg Renée
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00073.x
Subject(s) - transferrin , proteinuria , medicine , urinary system , albumin , creatinine , renal function , excretion , endocrinology , urine , urology , kidney , gastroenterology
Serum and urinary transferrin have been determined in 35 patients with renal disease and in 12 patients with urinary tract tumour. The relative content of transferrin in serum proteins did not differ significantly between patients with different diseases. The urinary protein content of transferrin was significantly higher in patients with glomerulonephritis than in patients with pyelonephritis. Patients with urinary tract tumour had a lower transferrin content than patients with pyelonephritis, but this difference was not significant. The clearance of transferrin and the clearance of albumin were approximately equal in patients with renal disease and the correlation between the clearance values was highly significant. There was also a significant correlation between the clearance of transferrin and that of IgG, but the deviation was greater. In patients with urinary tract tumour no significant correlation was found between the clearance of transferrin and that of albumin or IgG. Serum content and renal clearance of transferrin were not correlated to Hb concentration, serum iron, or creatinine, and no difference in this respect was found between patients with a positive urine culture and non‐infected patients. It is concluded that the renal clearance of transferrin depends on the molecular size. The nature of the renal disease causing proteinuria may influence the relationship between the renal excretion of transferrin and that of other proteins of different molecular size. Proteinuria originating from the lower urinary tract may have a different composition from the one of renal origin.