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INTRAVENOUS NUTRITION WITH AMINO ACID SOLUTIONS IN PATIENTS WITH CHRONIC URAEMIA
Author(s) -
Bergström J.,
Bucht H.,
Fürst P.,
Hultman E.,
Josephson B.,
Norée L.O.,
Vinnars E.
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00065.x
Subject(s) - histidine , amino acid , medicine , nitrogen balance , arginine , urea , creatinine , essential amino acid , nitrogen , biochemistry , chemistry , organic chemistry
Studies are reported dealing with nutrition of patients in terminal uraemia by i.v. infusions of solution of the essential amino acids supplementing a diet with a low, standardized nitrogen content. The basic amino acids were neutralized with acetic acid. Most of the patients had a creatinine clearance below 5 ml/min. The nitrogen balance improved in all patients except in a few cases with intercurrent complications. In most cases the plasma urea concentration decreased concomitantly. The beneficial effect of the essential amino acids on the nitrogen balance and the plasma urea was enhanced by the addition of histidine and also of both histidine and arginine to the amino acid solution.