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DRUG‐INDUCED MALABSORPTION OF VITAMIN B 12
Author(s) -
Palva I. P.,
Salokannel S. J.,
Timonen T.,
Palva H. L. A.
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00064.x
Subject(s) - malabsorption , medicine , vitamin b , gastroenterology , potassium , intestinal malabsorption , vitamin , drug , endocrinology , pharmacology , chemistry , coeliac disease , disease , organic chemistry
In a series of 60 patients on KCl treatment the Schilling test was abnormal (below 5%) in 12%, slightly reduced (5 to 10%) in 18% and normal (above 10%) in 70%. Radiotelemetric measurement of the ileal pH in 21 partients showed an acidification of the ileal contents to be the mechanism of the B 12 malabsorption found. In 10 patients with an ileal pH of 6 or below, the Schilling test was on average 7.8%. and in those 11 with a pH levels of corresponding figure was 13.4%. The serum levels of vitamin B 12 in 17 heart patients taking KCl over a period of 6 to 24 months were, however, not significantly lower than those of the control group. Potassium chloride induces malabsorption of vitamin B 12 in some patients, but in rare instances is the regular potassium supplementation of long enough duration to be the only factor causing the deficiency state of B 12 .