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HEMODYNAMIC EFFECTS OF METHOXAMINE IN PATIENTS WITH LEFT‐TO‐RIGHT SHUNTS
Author(s) -
Abrahamsen Arne M.,
Grendahl Helge,
Müller Carsten
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00052.x
Subject(s) - medicine , methoxamine , cardiology , vascular resistance , pulmonary wedge pressure , cardiac output , hemodynamics , pulmonary artery , ductus arteriosus , stroke volume , blood pressure , anesthesia , pulmonary hypertension , arteriovenous oxygen difference , heart rate , receptor , agonist
In nine patients with atrial septal defect (ASD), five with ventricular septal defect (VSD) and one with persistent ductus arteriosus (PDA) hemodynamic examinations have been performed before and after injection of the vasopressor agent methoxamine. On an average 8 mg methoxamine was injected into the pulmonary artery. An insignificant increase of the left‐to‐right shunt was observed. Significant changes were decrease of heart rate, increase of systemic systolic pressure, mean pulmonary capillary wedge pressure and arteriovenous O 2 ‐difference. Stroke volume and systemic arteriolar resistance increased, and these changes were significant in ASD, insignificant in VSD. The rise in pulmonary arterial mean pressure and oxygen consumption, reduction in cardiac output and pulmonary arteriolar resistance were insignificant.