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C‐CELLS IN NON‐MALIGNANT HUMAN GOITERS STUDIED IN FINE‐NEEDLE ASPIRATION BIOPSY SPECIMENS
Author(s) -
Nilsson Göran
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00047.x
Subject(s) - medicine , fine needle aspiration , goiter , pathology , thyroid , malignancy , thyroiditis , biopsy , giemsa stain
It was recently shown that in May–Grünwald–Giemsa stained smears obtained from thyroid medullary carcinomas by fine‐needle aspiration the malignant C‐cells have a very distinctive morphology with a bright red cytoplasmic granulation and rather characteristic nuclei as specific features. This enabled the author to detect corresponding cells in fine‐needle aspirates also from nonneoplastic goiters. These presumed C‐cells proved to be more common in toxic goiters than in cases of lymphoid thyroiditis and atoxic goiters without signs of malignancy or thyroiditis. In toxic goiters their occurrence showed a statistically significant positive correlation with the ( 125 I) T 3 ‐uptake. They also were found to be more scarce in older than younger age groups.