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ADRENERGIC α‐ AND β ‐RECEPTORS IN CORONARY VESSELS IN MAN
Author(s) -
Andersson Rolf,
Holmberg Stig,
Svedmyr Nils,
Åberg Gunnar
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00045.x
Subject(s) - contraction (grammar) , medicine , adrenergic , blockade , receptor , endocrinology , adrenergic receptor , epinephrine , cardiology
The occurrence of adrenergic receptors has been investigated in vitro in isolated human coronary vessels from a newly dead 30‐year‐old man. Both noradrenaline and adrenaline easily contracted the originally atonic coronary vessels. This contraction was strengthened after blockade of the β ‐receptors with a specific adrenergic β ‐blocker (sotalol, MJ 1999). The contraction increased with the dosage and was completely blocked by an adrenergic α‐blocker (dibenamine). Adrenaline had a somewhat stronger contracting effect than noradrenaline. The contraction was stronger in larger coronary vessels (diameter 2 mm) than in small (diameter 0.5 mm). On coronary vessels contracted by addition of potassium chloride to a final concentration of 13 μ moles/ml, both noradrenaline and adrenaline (1.7 × 10 –7 g/ml) produced relaxation, the effect of adrenaline being somewhat stronger. After adrenergic β ‐blockade this relaxing effect of adrenaline and noradrenaline was completely blocked. The occurrence of both α‐ and β ‐receptors has thus been shown in human coronary vessels.