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HEREDITARY ANGIONEUROTIC OEDEMA IN THREE FAMILIES
Author(s) -
Blohmé G.,
Ysander L.,
KorsanBengtsen K.,
Laurell A.B.
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00040.x
Subject(s) - medicine , abdominal pain , abnormality , pregnancy , disease , peripheral edema , pediatrics , adverse effect , psychiatry , genetics , biology
Abstract Three families from the western part of Sweden with hereditary periodic oedema (HANE) are reported. Complement analyses were performed in 11 of 21 members of the families. They all have the biochemical abnormality characterizing this disease, with low values of CI INH. The symptoms of HANE are not the same from patient to patient, nor in the same patient from attack to attack. The frequency of peripheral oedema, abdominal pain and other symptoms were studied. The influence of menstrual period and pregnancy are discussed. Therapeutic trials with methyltestosterone and aminocaproic acid are reported.