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DIFFERENT SERUM INSULIN PATTERNS IN PORTAL, HEPATIC AND PERIPHERAL VENOUS BLOOD IN TWO CASES OF INSULOMA
Author(s) -
Erwald R.,
Hed R.,
Marions O.,
Nandorf R.,
Nygren A.,
Röjdmark S.,
Sundblad L.,
Wiechel K.L.
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00033.x
Subject(s) - hyperinsulinemia , tolbutamide , medicine , insulin , endocrinology , venous blood , peripheral , stimulation , insulin resistance
Insulin secretion has been studied in two cases of insuloma. In one of them neither fasting hyperinsulinemia nor excessive insulin release in response to glucose ingestion or tolbutamide administration could be demonstrated. This patient belonged to a family in which pronounced insulin responsiveness was observed. In the other case, with hypoglycemic attacks and hyperinsulinemia following β ‐cell stimulation, a higher insulin level was observed in hepatic venous blood than in portal blood, indicating extrapancreatic insulin‐producing tissue.