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ON THE METABOLISM OF FAT AND CARBOHYDRATE IN A PATIENT WITH REFRACTORY SIDEROBLASTIC ANAEMIA
Author(s) -
Hagenfeldt Lars,
Hellström Kjell,
Rosenqvist Urban
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00011.x
Subject(s) - endocrinology , medicine , urinary system , excretion , metabolism , refractory (planetary science) , biology , astrobiology
A patient with an acquired refractory sideroblastic anaemia has been studied. The anaemia had many features in common with pernicious anaemia, but high level of vitamin B 12 and a normal urinary excretion of methylmalonate excluded vitamin B 12 deficiency. A decreased pyruvate utilization and an increased urinary ex‐creation of acetate were demonstrated. Studies in vitro with white blood cells indicated a decreased efficiency of tricarboxylic acid cycle oxidation due to a low citrate synthetase activity. All serum lipid fractions were low, and a decreased lipolytic response to exercise and isoprenaline infusion was observed. The pathogenesis of these changes is discussed.