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COMBINED CHLORAMBUCIL AND PREDNISOLONE TREATMENT OF FIVE PATIENTS WITH WEGENER'S GRANULOMATOSIS
Author(s) -
Berglund G.,
Hansson L.,
Persson B.,
Vikgren P.
Publication year - 1972
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1972.tb00002.x
Subject(s) - chlorambucil , medicine , prednisolone , diathesis , surgery , phenprocoumon , disease , hemorrhagic diathesis , pediatrics , chemotherapy , cyclophosphamide , immunology , warfarin , atrial fibrillation
Five patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone. Three patients are in good general condition 48, 14 and 8 months after commencement of this therapy and with improved of stable renal function. Two patients died. For one of the latter, therapy was started late in the course In the disease and could not prevent the fatal outcome. In the other fatal case chlorambucil could not be maintained at an adequate dosage because of complicating hemorrhagic diathesis. On the basis of the experience gained from our own and earlier reported results, a rational treatment of the disease is proposed.