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Chromosome fragility in the Lennox‐Gastaut epilepsy syndrome
Author(s) -
SMITH A.,
BERAN R. G.
Publication year - 1992
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1992.tb00561.x
Subject(s) - lennox–gastaut syndrome , epilepsy , fragility , fragile x syndrome , cohort , pediatrics , chromosome analysis , down syndrome , chromosome , turner syndrome , medicine , karyotype , biology , genetics , psychiatry , chemistry , gene
. Chromosome fragility was sought in a weil‐defined cohort of patients with Lennox‐Gastaut epilepsy syndrome. Twenty‐five patients plus 25 age‐ and sex‐matched normal controls had cytogenetic studies performed. All patients were taking sodium valproate, and four were also on hydantoin. Blood cultures from both patients and controls were set up simultaneously in an appropriate medium designed to elicite fragile‐sites. Harvesting took place after 96 h by standard techniques. In addition to routine banded analysis, at least 50 cells were scored for chromosome breaks and gaps from each patient and control. Results showed no difference between the patients and the control group in the overall occurrence of fragility or the type of aberration detected. No fragile‐X syndrome was detected. This study found no effect due to sodium valproate on the occurrence of chomosome aberrations.