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Vaccination against hepatitis B in preschool children with Down's syndrome
Author(s) -
VAJRO P.,
LETTERA P.,
FONTANELLA A.,
SBREGLIA C.,
MANZILLO E.,
SARTORIO R.,
GIUDICE E.
Publication year - 1992
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1992.tb00472.x
Subject(s) - vaccination , seroconversion , medicine , hbsag , down syndrome , pediatrics , hepatitis b , hepatitis b virus , immunization , hepatitis a virus , immunology , virology , immune system , virus , psychiatry
. Twenty‐nine healthy HBsAg‐ and HBsAb‐negative children with Down's syndrome who were living at home (mean age 42 months; 19 M, 10 F) were vaccinated against hepatitis B virus either with recombinant DNA or plasma‐derived vaccine. Both groups of children responded well to the vaccination schedules, with HBsAb seroconversion rates close to 100%. Vaccination against hepatitis B in preschool children with Down's syndrome is effective in spite of the existing abnormalities of the immune function.