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Down's syndrome and thyroid disorder
Author(s) -
DINANI S.,
CARPENTER S.
Publication year - 1990
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1990.tb01528.x
Subject(s) - thyroid , medicine , endocrinology , thyroid function , hormone , anti thyroid autoantibodies , antibody , autoantibody , immunology
. The thyroid status of 106 adults with Down's syndrome was assessed. Six were previously diagnosed as hypothyroid and were already receiving thyroxine. A further 37 patients showed abnormal thyroid function. Biochemical evidence of hypothyroidism (T4 < SO nmol/1 and T.S.H.>4 mu/<) was found in one person. Six patients were found to have an unequivocally elevated T.S.H. but normal T4 (T4>50 nmol/l and T.S.H.>20 mu/1) and 29 were found to have a modest elevation of T.S.H. but normal T4 concentration (T4>50 nmol/1 and T.S.H. between 4 and 20 mu/l). There was one patient with milJ thyroloxicosis (T4= 180 nmol/1 and T.S.H.<0.1 mu/l). Clinical findings were of little use in making a diagnosis of hypothyroidism in this group of patients. A raised level of thyroid microsomal auto‐antibodies was found in about a third of the patients, this occurred more commonly in females and slightly more often in those with a raised thyroid stimulating hormone. The importance of this is discussed. Recommendations for regular biochemical screening are made.