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Vitamin E and Alzheimer's disease in subjects with Down's syndrome
Author(s) -
JACKSON C. V. E.,
HOLLAND A. J.,
WILLIAMS C. A.,
DICKERSON J. W. T.
Publication year - 1988
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1988.tb01439.x
Subject(s) - disease , down syndrome , medicine , alzheimer's disease , psychology , gerontology , pediatrics , psychiatry
. People with Down's syndrome (DS) are at high risk of developing Alzheimer's disease (AD). The gene coding for Superoxide dismutase‐/ on chromosome 21 resulting in excess activity of the enzyme with consequent risk of oxidative damage might account for the premature ageing. Vitamin E protects against such damage. Plasma vitamin E levels measured in 12 DS subjects with AD (8.19·0.77 μg/ml) were lower (P<0.05) than in 12 DS controls (9.43·1.57 μg/ml). It is suggested that there may be an interaction between risk of AD and the protective action of vitamin E.