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Auditory P300 response in the assessment of Alzheimer's disease in Down's syndrome: a 2‐year follow‐up study
Author(s) -
MUIR W. J.,
SQUIRE I.,
BLACKWOOD D. H. R.,
SPEIGHT M. D.,
CLAIR D. M.,
OLIVER C.,
DICKENS P.
Publication year - 1988
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1988.tb01437.x
Subject(s) - dementia , down syndrome , audiology , psychology , alzheimer's disease , medicine , disease , pediatrics , psychiatry
. Sixty‐five subjects with Down's syndrome were followed up and retested 2 years after the initial recording ni auditory P300 (P3) event‐related potential described in a companion paper (Blackwood et al. , 1988). The number of subjects showing clinical evidence for Alzheimer's type dementia had increased by a further 14%. In subjects showing clinical deterioration over a period of 2 years, 78% (7/9) had an increase in P3 latency which was three standard deviations or greater than the group mean. None of the 20 fragile‐X group retested showed significant change after 2 years. The results suggest that P3 change may be a sensitive index of the onset of Alzheimer's type dementia in Down's syndrome.