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A DOUBLE BLIND STUDY OFVITAMIN B 6 IN DOWN'S SYNDROME INFANTS. PART 1—CLINICAL AND BIOCHEMICAL RESULTS
Author(s) -
Coleman Mary,
Sobel Suzanne,
Bhagavan Hemmige N.,
Coursin David,
Marquardt Anne,
Guay Marie,
Hunt Carl
Publication year - 1985
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1985.tb00333.x
Subject(s) - medicine , library science , psychology , computer science
Nineteen patients with Down's syndrome participated in a double blind study of the clinical effects of pharmacological doses of vitamin B6 administration, starting under 8 weeks of age and continuing until 3 years of age. Ten patients received the vitamin and nine the placebo. In Part 1 of this study, no statistically significant differences were found between the two groups in mental age, height, weight, cranial circumference or tongue protrusion. A study of side effects conducted on a larger open population found vitamin B6 to be relatively safe when administered over long periods of time with photosensitive blisters as the major complication.