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THE HIPPOCAMPUS IN DOWN'S SYNDROME
Author(s) -
Sylvester P. E.
Publication year - 1983
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1983.tb00294.x
Subject(s) - citation , psychology , library science , medicine , computer science
Evidence is presented from area measurements of the end folia (dentate gyrus) and pyramidal cell layer of the hippocampus in adults with Down's syndrome that these structures are significantly smaller than those found in control subjects. This is likely to be largely due to congenital malformation. The observation is supported by the fact that these structures in a Down's fetus were not so well formed as in a non-Down's fetus of equivalent age. Significant functional repercussion in memory processes and intellectual potential as well as in risk of developing ageing disease may follow hippocampal maldevelopment.