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THE COMPOSITION OF TUBEROUS SCLEROSIS GREY MATTER
Author(s) -
FISCHER M. H.,
MATTHEWS L. M.,
ARYA S.,
VISESKUL C.
Publication year - 1981
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1981.tb00088.x
Subject(s) - tuberous sclerosis , grey matter , composition (language) , multiple sclerosis , psychology , medicine , white matter , psychiatry , magnetic resonance imaging , philosophy , radiology , linguistics
The chemical analysis of grey matter from a tuberous sclerosis subject indicated the presence of two different types of grey matter based on two distinctly different ganglioside concentrations. Both samples had gangliosides of reduced concentration with an abnormal composition compared to normal grey matter as evidenced from their thin-layer chromatography profiles. Analyses of the glycoprotein fraction from both samples revealed increased glycoprotein content, particularly in total carbohydrate. This observation was consistent with previous studies of angiofibromas and angiomyolipomas.