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ANEUPLOIDY IN CULTURE
Author(s) -
SMITH ARABELLA,
ELLIOTT GAE
Publication year - 1980
Publication title -
journal of intellectual disability research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1980.tb00070.x
Subject(s) - aneuploidy , karyotype , chromosome , significant difference , biology , genetics , andrology , ploidy , medicine , gene
On one hundred consecutive clinically referred patients, a total of 3,175 cells was fully analysed. The parameters of culture and analysis were the same for all patients, and a breakdown of cells showed 258 cells (8.1 per cent) with hypomodal counts and sixty-two cells (1.9 per cent) with hypermodal counts. The great majority of the hypomodal cells contained forty-five chromosomes and the distribution of chromosome loss from these cells was non-random, with fewer than expected of the large chromosomes (groups A, B and C) being lost, and more than expected of the small chromosomes (group E and G) being lost. The distribution of the chromosomes gained in the hypermodal cells was random (except for the C group where the numbers were small). In this data, there was no significant difference of aneuploidy in culture noted for sex, age, or patient referral group.