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SERUM CHOLINESTERASE (PSEUDOCHOLINESTERASE) IN DOWN'S SYNDROME: 2. QUANTITATIVE LEVELS
Author(s) -
DREW ANNE H.,
RUNDLE A. T.
Publication year - 1977
Publication title -
journal of intellectual disability research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.1977.tb00038.x
Subject(s) - citation , medicine , classics , psychology , library science , art , computer science
The observation elsewhere (Drew and Rundle, 1977) that increase frequencies of the C5 + variant of the serum cholinesterase in Down's syndrome may be due to a protective influence against adverse environmental factors has been investigated for such factors as age, sex, duration of institutionalisation, presence of the hepatitis -B antigen and maternal age. With the exception of the maternal age none of the factors tested appear to affect the circulating levels of cholinesterase. A maternal age effect in the Down's subjects was detected with lower levels of the enzyme being found in the subject positive for the C5 + variant born to mothers over thirty-five years when compared to the C5 + subjects born to mothers under thirty-five years. Further studies confirmed the presence of a relationship between maternal age, serum cholinesterase levels and haptoglobin phenotypes.