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Herpesviral haematopoietic necrosis of goldfish, Carassius auratus (L.)
Author(s) -
JUNG S. J.,
MIYAZAKI T.
Publication year - 1995
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/j.1365-2761.1995.tb00296.x
Subject(s) - biology , lamina propria , carp , carassius auratus , spleen , virology , necrosis , microbiology and biotechnology , anatomy , epithelium , immunology , fishery , fish <actinopterygii> , genetics
Abstract. In the spring of 1992 and 1993, an epizootic with severe mortality occurred among cultured goldfish. Carassius auratus (L.), in Aichi and Nara Prefectures in Japan. A herpes‐virus was isolated from moribund goldfish that induced cytopathic effects in FHM and EPC cells. The isolate was sensitive to IUdR (5‐iodo‐2‐deoxyuridine), acid (pH 3) and ether. Transmission studies confirmed the pathogenicity of the viral isolate for goldfish while it was not pathogenic for fancy carp, Cyprinus carpio L. Diseased fish had no visible external signs except for listlessness, but internally there was softening and discolouration of the spleen and kidney, and necrotic foci in the haematopoietic tissue, splenic pulp, pancreas, and lamina propria and submucosa of the intestine. Electron microscopy revealed enveloped visions ranging from 170 to 220nm in diameter with hexagonal nucleocapsids (115–117nm edge‐to‐edge diameter). The disease has been designated as herpesviral haematopoietic necrosis (HVHN), and to date, is the only herpesvirus infection to be described in goldfish.