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Toxicity of intraperitoneally injected formalin in Atlantic salmon, Salmo salar L.
Author(s) -
NILSEM H.,
LILLEHAUG A.,
TAKSDAL T.,
NORDMO R.
Publication year - 1992
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/j.1365-2761.1992.tb00670.x
Subject(s) - salmo , benzocaine , biology , formaldehyde , toxicity , fish <actinopterygii> , toxicology , zoology , veterinary medicine , fishery , microbiology and biotechnology , physiology , medicine , immunology , biochemistry
. Atlantic salmon, Salmo salar L., parr were injected intraperitoneally with different quantities of formalin (37% formaldehyde) following anaesthetization with either benzocaine (ethyl‐p‐aminobenzoate) or chlorbutol (1,1,1,‐trichloro 2‐methyl‐2‐propanol) The LD 50 for injected formaldehyde was found to be approximately 50mg kg −1 body weight. The type and concentration of the anaesthetic used did not influence mortality rates. Formalin is commonly used to inactivate microorganisms in vaccines. Doses of formalin which were shown to be toxic in this study are close to those which may be injected into fish as a component of various vaccines against bacterial fish diseases. Hence, the formalin content in fish vaccines may well cause mortality under certain conditions.