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Rhabdomyosarcoma in the Japanese medaka, Oryzia latipes (Temminck & Schlegel) and guppy, Poecilia reticulata Peters
Author(s) -
HAWKINS W. E.,
FOURNIE J. W.,
OVERSTREET R. M.,
WALKER W. W.
Publication year - 1988
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/j.1365-2761.1988.tb00547.x
Subject(s) - oryzias , poecilia , guppy , biology , rhabdomyosarcoma , juvenile , zoology , fish <actinopterygii> , anatomy , pathology , sarcoma , genetics , fishery , medicine
. Three cases of skeletal muscle neoplasms occurring in two small fish species used in carcinogen tests are reported. The cases illustrated a wide range of histologic patterns, and consisted of a well‐differentiated juvenile type, a well‐differentiated pleomorphic type and a poorly differentiated pleomorphic type. A rhabdomyosarcoma with juvenile type features developed in the Japanese medaka, Oryzias latipes , exposed to 0·5 ml/1 of the solvent dimethylformamide. A pleomorphic type rhabdomyosarcoma occurred in one medaka and in one guppy, Poecilia reticulata , exposed to the carcinogen methylazoxymethanol acetate. These cases indicate the potential for skeletal muscle cells in medaka and guppy to become neoplastic but, because the tumours occurred at a low frequency, there may not necessarily be a chemical aetiology.