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Effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) or Aroclor 1254 on the resistance of rainbow trout, Salmo gairdneri Richardson, to infectious haematopoietic necrosis virus
Author(s) -
SPITSBERGEN J. M.,
SCHAT K. A.,
KLEEMAN J. M.,
PETERSON R. E.
Publication year - 1988
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/j.1365-2761.1988.tb00524.x
Subject(s) - rainbow trout , salmo , biology , tetrachlorodibenzo p dioxin , virus , infectious hematopoietic necrosis virus , toxicant , trout , necrosis , toxicity , polychlorinated biphenyl , virology , fish <actinopterygii> , medicine , fishery , ecology , genetics
. Sublethal exposure of rainbow trout fry, Salmo gairdneri Richardson, to polychlorinated biphenyls (PCBs) or 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) did not significantly affect mortality or mean time to death following challenge with infectious haematopoietic necrosis virus (IHNV). Rainbow trout fry were fed experimental diets containing 0, 5. 50 or 500 μg/g of the technical polychlorinated biphenyl mixture, Aroclor 1254, for 30 days or were injected intraperitoneally with graded single doses of TCDD. Fish from each treatment group were challenged by immersion exposure to IHNV. At early time points following virus challenge, histopathologic lesions due to virus disease were more severe and occurred more frequently in virus‐challenged fish which received either toxicant than in virus‐challenged control fish. Taken together, these findings suggest that rainbow trout are less sensitive than mammalian species to the sublethal effects of these structurally related toxicants on resistance to viral disease. However, a subtle effect of these chemicals on the pathogenesis of the virus disease is suggested by the histopathologic data.