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The influence of antibiotics on the immune system: immuno‐pharmokinetic investigations on the primary anti‐SRBC response in carp, Cyprinus carpio L., after oxytetracycline injection
Author(s) -
GRONDEL J. L.,
NOUWS J. F. M.,
MUISWINKEL W. B.
Publication year - 1987
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/j.1365-2761.1987.tb00716.x
Subject(s) - cyprinus , oxytetracycline , carp , biology , antibody , antibody response , pharmacokinetics , immune system , immunization , common carp , adjuvant , zoology , antibiotics , andrology , pharmacology , medicine , immunology , microbiology and biotechnology , fishery , fish <actinopterygii>
. The present study was performed to obtain further details on the immuno‐modulating effects of oxytetracycline (OTC) in carp, Cyprinus carpio L. The immuno‐logical study was extended by investigating the pharmacokinetic behaviour of OTC. Oxytetracycline, at a dosage of 60 mg/kg, was administered five times intra‐peritoneally at 3‐day intervals; the first injection was given 1 day before immunization. The kinetics of the primary anti‐sheep red blood cell (SRBC) response, during a short‐term OTC treatment revealed that the kinetics of the plaque‐forming cell (PFC) response was not significantly affected by OTC nor its solvent. In contrast, the number of plaque‐forming cells was significantly decreased. The anti‐SRBC antibody production was delayed by 2–4 days in both experimental groups (OTC and solvent). However, within 12–14 days post‐immunization, the same antibody levels were detected as in the control group. High OTC plasma levels (>50 μg/ml) were detected about 10 h after a single i. p. injection. A mean plasma elimination half‐life (T 1 / 2 ) of 34·5 h was calculated.