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Influence of dietary selenium on the occurrence of nephrocalcinosis in the rainbow trout, Salmo gairdneri Richardson
Author(s) -
HICKS B. D.,
HILTON J. W.,
FERGUSON H. W.
Publication year - 1984
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/j.1365-2761.1984.tb01202.x
Subject(s) - nephrocalcinosis , rainbow trout , selenium , salmo , medicine , endocrinology , calcium , biology , kidney , fish <actinopterygii> , chemistry , fishery , organic chemistry
Rainbow trout were fed practical‐type diets containing 0.6, 6.6 and 114 μ g/g selenium for 16 weeks at approximately 15°C. Fish reared on the highest levels of dietary selenium had a significant reduction in final body weight, feed: gain ratio and increased mortality. Haematocrit, plasma calcium, glucose, and protein levels did not vary significantly. Ninety per cent of the fish fed the diet containing the highest level of selenium developed nephrocalcinosis. Fish with occult nephrocalcinosis had significantly increased levels of kidney calcium and those with overt nephrocalcinosis had significantly increased levels of kidney calcium and magnesium, and liver magnesium. Microscopically, the majority of renal damage was tubular with the renal interstitium becoming inflamed only when tubules degenerated. The pathogenesis of selenium‐induced nephrocalcinosis is discussed.