Premium
Egtved virus: temperature‐dependent immune response of trout to infection with low‐virulence virus
Author(s) -
JØRGENSEN P. E. VESTERGÅRD
Publication year - 1982
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1111/j.1365-2761.1982.tb00455.x
Subject(s) - biology , virus , immune system , salmo , rainbow trout , virology , trout , virulence , strain (injury) , antibody , microbiology and biotechnology , fish <actinopterygii> , immunology , gene , fishery , genetics , anatomy
. The present report deals with experiments concerning the theoretical basis for development of a live, attenuated vaccine against viral haemorrhagic septicaemia (VHS) of rainbow trout, Salmo gairdneri Richardson, on the basis of a virus strain derived from the Egtved virus reference strain F, the pathogenicity of which has been strongly reduced by in vitro passage. It is shown that the low pathogenicity of the virus (designated the Reva strain) is a genetically stable feature and that the protection against VHS induced by infection with the virus is due to an immune response. Following immunological priming at 10°C partial protection developed at 5° 10° and 15° but not at 20°C, whereas neutralizing antibody was produced at all four temperatures by some of the fish. The duration of virus persistence in trout was found to be inversely proportional to the water temperature.