Premium
New treatment of free‐radical scavenger in adrenoleukodystrophy
Author(s) -
Kawashima H.,
Nishimata S.,
Ishii C.,
Yamanaka G.,
Kashiwagi Y.,
Takekuma K.,
Hoshika A.,
Watanabe Y.
Publication year - 2011
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2011.01267.x
Subject(s) - adrenoleukodystrophy , edaravone , free radical scavenger , scavenger , chemistry , medicine , anesthesia , pharmacology , radical , biochemistry , antioxidant , peroxisome , receptor
Summary What is known and Objective: Adrenoleukodystrophy (ALD) is an X‐linked disorder and characterized by the accumulation of saturated very long‐chain fatty acids. Treatment is still unsatisfactory. Our objective is to report on the effect of the free‐radical scavenger, edaravone, in a patient with ALD. Case summary: The patient was given edaravone intravenously twice. D‐ROM in cerebral spinal fluid decreased dramatically, and a shortening of neuronal transmission time as estimated on somatosensory evoked potential was observed. After terminating the treatment, his symptoms progressively reappeared. What is new and Conclusion: This is the first report of the use of edaravone in ALD. The drug is apparently effective in improving symptoms of ALD and should be evaluated more formally.