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The effect of high dose of N ‐acetylcysteine in lupus nephritis: a case report and literature review
Author(s) -
Tewthanom K.,
Janwitayanujit S.,
Totemchockcyakarn K.,
Panomva Ayudhya D.
Publication year - 2010
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/j.1365-2710.2009.01108.x
Subject(s) - lupus nephritis , acetylcysteine , medicine , systemic lupus erythematosus , pharmacology , dermatology , chemistry , organic chemistry , antioxidant , disease
Summary An imbalance of oxidative–antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co‐administration of N ‐acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46‐year‐old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well‐controlled trial is needed to confirm the value of high‐dose NAC in lupus nephritis patients.